Isenolic® Olive Leaf Extract: Nature's Answer to Seasonal Immune Support

Written by: MakeWell

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Published on

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Time to read 5 min

Are you searching for natural immune support that actually works? If you've been looking for immune system supplements that can help you stay resilient during cold and flu season, you're not alone. Millions of people are discovering the benefits of research-backed natural ingredients, such as olive leaf extract, for maintaining long-term immune health.

The Challenge with Seasonal Immune Health

Every year, as cold and flu season approaches, many of us find ourselves caught in the same frustrating cycle: getting sick, recovering, then getting sick again. While conventional approaches focus on treating symptoms after you're already unwell, what if there was a better way to support your body's natural defences before illness takes hold?


Your immune system is incredibly complex, working constantly to protect you from seasonal threats. The good news? Natural immune support offers a proactive approach to staying healthy year-round.

What Makes Premium Immune System Supplements Different?

The key to effective natural immune support lies in understanding how certain plant extracts can work in harmony with your body's natural defences, rather than just masking symptoms. This is where standardised botanical extracts, such as Isenolic® (a standardised form of olive leaf extract), come into play.

Isenolic®: Advanced Olive Leaf Extract for Immune Defence

One of the key ingredients in our Immune Defence formula is Isenolic®, a premium olive leaf extract that surpasses traditional olive leaf supplements. While you might know olive leaf from its historical use in Mediterranean medicine, Isenolic® represents cutting-edge botanical science.


What sets Isenolic® apart as a natural immune support ingredient:


Standardised potency: Unlike other olive leaf extracts, Isenolic® contains guaranteed levels (≥4%) of elenolic acid, an active compound responsible for antiviral activity


Consistent results: Each dose delivers the same therapeutic compounds for reliable immune support


Research-backed: Scientific studies demonstrate effectiveness specifically against influenza viruses


Premium quality: Non-GMO, sustainably sourced in Spain, with multiple quality certifications, including Kosher and Halal

How Isenolic® Supports Your Immune System Naturally

Here's what makes Isenolic® unique among immune health supplements: it works through multiple pathways simultaneously to support your body's natural defences.


The Multi-Targeted Advantage


Unlike single-action ingredients, Isenolic® provides comprehensive immune support through mainly four different mechanisms:


Direct Viral Defence:


  • Works inside cells to help stop viral replication

  • Disrupts processes that viruses need to survive and spread

  • Helps contain viral infections before they take hold

  • Promotes viral disruption via a process called Phagocytosis


Immune System Activation:


  • Supports your body's natural immune response

  • Helps activate protective immune cells

  • Promotes your body's ability to fight off seasonal threats


Protective Barrier Support:


  • Helps prevent viruses from spreading between cells

  • Supports your body's natural barriers against infection

  • May help influence the duration of seasonal illness


Scientific Research: Real Results for Immune Support


The research behind Isenolic® for immune support is impressive. In laboratory studies comparing Isenolic® directly with Oseltamivir (a gold standard antiviral medication), researchers found that Isenolic® demonstrated:


  • Strong antiviral activity comparable to conventional medications

  • Protection for healthy cells against viral infection

  • Potential as both an effective and well-tolerated natural alternative


These aren't just laboratory results—they represent genuine potential for natural immune support backed by rigorous scientific investigation.

Immune Defence: Comprehensive Seasonal Wellness

Understanding that immune health requires multi-faceted support, we created Immune Defence to combine Isenolic® with other research-backed natural ingredients. This comprehensive approach addresses multiple aspects of immune wellness throughout the cold and flu season.


The Synergy Advantage


When natural immune-support ingredients work together, they create a synergy effect, where the combined result exceeds what any single ingredient could achieve alone. This means:


  • Enhanced effectiveness from the complete formula

  • Gentler approach using balanced doses of individual ingredients

  • Comprehensive support for multiple immune processes


Why Choose Immune Defence for Natural Immune Support


Research-Backed Formula:


  • Ingredients selected based on clinical evidence

  • Standardised extracts for consistent potency

  • Comprehensive immune support approach


Seasonal Protection:


  • Designed for daily use during cold and flu season

  • Supports both prevention and acute immune needs

  • Suitable for long-term use

  • Gentle on your system


The Formula 


Ester-C® (Buffered Vitamin C): Essential for normal immune system function, with enhanced tolerability, gentler on the stomach than regular vitamin C.


Astragalus: Used for centuries in traditional medicine, research shows it helps support immune cell activity and healthy inflammatory responses.


Cordyceps: This adaptogenic mushroom helps balance both rapid and long-term immune responses, supporting your body's ability to respond appropriately to threats.


β-Glucans: These special compounds from yeast may support your immune system by interacting with immune cells in your gut, where much of your immune system resides.


Rhodiola: Stress can weaken your immune defences. This adaptogen helps your body manage stress while supporting healthy immune function.

Our Approach

If you've been searching for effective natural immune support, Immune Defence offers a research-backed approach that works with your body's natural defences. This isn't about quick fixes or just treating symptoms—it's about supporting your immune system's natural ability to keep you healthy throughout the cold and flu season.


Whether you're looking to stay healthy during winter months, support your recovery after illness, or simply give your immune system the comprehensive support it deserves, Immune Defence provides the evidence-based ingredients your body needs.

We always recommend consulting with a healthcare professional before introducing any new supplement, as they are best positioned to assess your individual needs and health history.

Always consult with your healthcare provider before starting any new supplement regimen, particularly if you have existing health conditions or are taking medications. Your healthcare provider can help determine the right approach for your individual needs and monitor for any potential interactions or side effects.

Isenolic® is a registered trademark of Pharmactive Biotech Products, S.L.U. Ester-C is a registered trademark of the Ester-C Company®

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References

Demirer, Büşra, and Gülhan Samur. "Health benefits of Olive Leaf: the Focus on Efficacy of Antiglycation mechanisms." Nutrition Reviews 83.3 (2025): 551-561.


European medicine agency Assessment report on Olea europaea L., folium; 31 January 2017 EMA/HMPC/359236/2016 Committee on Herbal Medicine


Salamanca, Aurora, et al. "Anti-influenza virus activity of the elenolic acid rich olive leaf (Olea europaea L.) extract Isenolic®." Antiviral Chemistry and Chemotherapy 29 (2021): 20402066211063391.


Duwe, Susanne C., et al. "Prophylaxis and treatment of influenza: options, antiviral susceptibility, and existing recommendations." GMS Infectious Diseases 9 (2021): Doc02.


Tepper, Viktoria, et al. "Influenza A/H4N2 mallard infection experiments further indicate zanamivir as less prone to induce environmental resistance development than oseltamivir." Journal of General Virology 101.8 (2020): 816-824.


nutraceuticalbusinessreview.com (New olive leaf study shows extract helps halt viral lifecycle; Published: 31-Mar-2020)


Zhang, Xueling, Xixi Qu, and Yu Zou. "The effect of Astragalus on humoral and cellular immune response: a systematic review and meta-analysis of human studies." Complementary medicine research 30.6 (2023): 535-543.


Lin, Bao Qin, and Shao Ping Li. "Cordyceps as an herbal drug." (2011): 73-105.


Stier, Heike, Veronika Ebbeskotte, and Joerg Gruenwald. "Immune-modulatory effects of dietary Yeast Beta-1, 3/1, 6-D-glucan." Nutrition journal 13.1 (2014): 38.


Pu, Wei-ling, et al. "Anti-inflammatory effects of Rhodiola rosea L.: A review." Biomedicine & Pharmacotherapy 121 (2020): 109552.